Technology Transfer & Investment and Financing Newsletter by MeritsIP, December 24, 2025
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Technology Transfer News
Hubei-produced Injectable Intelligent Nanorobots Achieve Breakthrough in Precision Tumor Therapy
On December 23rd, the research team led by Professor Guan Jianguo from Wuhan University of Technology achieved a crucial breakthrough in the field of precision tumor therapy with injectable intelligent nanorobots. The relevant results have been published in the authoritative journal National Science Review. This achievement has been successfully transferred to Wuhan Xinsheng Technology Co., Ltd. and entered the clinical transformation stage, providing a new technical solution for precision tumor therapy. It is reported that the core of the nanorobots developed by the team is “double-sided” nanoparticles. Its innovation lies in modifying two specific enzyme molecules on one side of the particles to construct an “enzymatic drive system” with both targeted navigation and power drive functions—one enzyme undertakes the targeted recognition function of a “steering wheel” and the other serves as the power supply function of an “accelerator”. It can accurately drive the nano-carrier to cross biological barriers and directionally deliver the loaded drugs to tumor tissue sites within a centimeter-level distance. Performance test results show that the nanorobots can increase the tumor targeting delivery efficiency by 200 times, and achieve a tumor inhibition efficiency of 92.7% with only 1% of the traditional dosage. This significantly reduces the toxic and side effects caused by drug off-targeting and greatly improves the cost-effectiveness of treatment, providing an effective technical path to solve core problems in tumor therapy such as poor targeting, high dosage, and strong side effects.
II. Three Class III Innovative Medical Devices Approved for Marketing in Jiangsu, Filling the Gap in Opioid Addiction Treatment Technology
The National Medical Products Administration recently approved the registration and marketing of three implanted deep brain stimulation-related products from Jingyu Medical Technology (Suzhou) Co., Ltd., namely stimulators, electrode leads, and extension leads. The three products jointly form an implanted deep brain stimulation system, marking that the number of Class III innovative medical devices approved in Jiangsu Province this year has reached 15. The core innovation of the system lies in the simultaneous action of a single electrode lead on the dual targets of the nucleus accumbens and the anterior limb of the internal capsule. It can independently set stimulation parameters such as frequency, amplitude, and pulse width to achieve synchronous and independent precise stimulation of the dual targets. It is suitable for the auxiliary treatment of relapse prevention in patients with refractory moderate to severe opioid addiction, filling the technical gap in physical intervention for this disease.
III. Mutation Law of Gene-edited Pigs Revealed for the First Time, Assisting Breakthrough in Xenotransplantation Safety
On December 22nd, the collaborative results of the team of Du Xiaoyan from Capital Medical University, the team of He Shunmin from the Institute of Biophysics of the Chinese Academy of Sciences, and the team of Pan Dengke from Chengdu Zhongke Aoge were published in Genomics, Proteomics & Bioinformatics. For the first time, the mutation accumulation law of GGTA1 gene-edited (GTKO) pigs and their offspring was analyzed at the whole-genome level, providing key scientific basis for the biosafety and clinical transformation of gene-edited donor pigs.
The study conducted whole-genome sequencing with an average depth of 110× on 5 GTKO-F0 generation pigs, 3 F1 generation pigs, and wild-type control pigs, drawing the first multi-generational mutation map. The results showed that among the average 1205 de novo mutations in the F0 generation, only about 8 might affect protein function and had no disease association. The mutations mainly originated from electroporation rather than CRISPR/Cas9 editing itself; the number of mutations in the F1 generation was equivalent to the spontaneous mutation rate, with good genetic stability. This study clarified the characteristics of mutations as “low-risk, heritable, and clear in origin”, proposed a standardized evaluation process and applied it to the donor pig production system, breaking the core bottleneck of clinical transformation of xenotransplantation and providing important technical support for solving the problem of organ shortage.
IV. Chinese Scientists Successfully Synthesize Hundreds-of-Micrometer-Scale Diamond Nanowire Single Crystals
On December 18th, the team of Li Kuo and Zheng Haiyan from the Center for High Pressure Science and Technology Advanced Research (HPSTAR) in Beijing, in conjunction with Tsinghua University and other institutions, published an important achievement in the international journal Chem: using high-pressure annealing technology, they successfully synthesized hundreds-of-micrometer-scale diamond nanowire single crystals from 1-naphthoic acid single crystals, breaking the long-standing bottleneck in the preparation of high-quality and large-size diamond nanowires in this field.
The study adopted a “single crystal to single crystal” topological chemical polymerization strategy, realizing efficient pre-stacking through the unique hydrogen bonding of 1-naphthoic acid molecules, and inhibiting defects through the synergistic effect of 20 gigapascals of high pressure and 573K annealing. A hexagonal diamond-like structure single crystal with a size of 140×100×20 micrometers was synthesized, laying a foundation for macro performance testing. This material has near-zero axial compressibility and extremely strong thermal conductivity anisotropy. The established controllable synthesis method of “molecular pre-design – high-pressure topological polymerization – annealing defect elimination” provides theoretical guidance for the design of low-dimensional carbon materials. The material remains stable at normal pressure, which is expected to promote the development of next-generation nanoelectronic devices and thermal management systems in various fields.
V. Dongfeng Dena EP12Max “Energy Efficiency King” Electric Drive Axle Debuts at Shanghai International Bus Show
On December 17th, the opening day of the 14th Shanghai International Bus Show (CIBE 2025), Dongfeng Dena Axle Co., Ltd. grandly released its strategic new product for the medium-capacity bus market—EP12Max “Energy Efficiency King” electric drive axle, with the theme of “Intelligent Bus Sharing, Win-Win Future”. More than 100 industry representatives, including the chairman of the Urban Public Transport Branch of the China Civil Engineering Society and the person in charge of many large bus companies across the country, witnessed the release.
The product is accurately adapted to the needs of various medium-capacity bus scenarios such as trunk lines in medium-sized cities, branch lines in large cities, and urban-rural connections. With four core advantages of “easy installation, energy saving, quiet ride, and easy maintenance”, it releases more interior space through structural optimization, achieves energy saving relying on an efficient electric drive system, improves ride comfort with excellent NVH performance, and reduces the whole-life cycle maintenance cost through modular design. The unveiling of the new product marks a new breakthrough in the technological upgrading of bus equipment. After the press conference, it attracted widespread attention from the industry. Many bus groups and overseas procurement teams conducted in-depth exchanges on technical details and adaptation schemes, demonstrating the market’s urgent demand for efficient and reliable bus equipment solutions.
VI. China’s First 2D Metal Preparation Achievement Selected into
Recently, Physics World hosted by the Institute of Physics (IOP) in the UK announced the list of “Top 10 Scientific Breakthroughs of 2025”. The achievement of “the first preparation of 2D metals” led by the team of Zhang Guangyu from the Institute of Physics of the Chinese Academy of Sciences was successfully selected. This is the 7th time that China-led research has received this honor, and it is also the only Chinese achievement selected this year, demonstrating that China has entered the international leading position in the field of atomic manufacturing of 2D materials.
The team developed an original technology, using self-developed atomically flat single-layer molybdenum disulfide anvils for extrusion, realizing the universal preparation of 2D metals with extreme angstrom-level thickness. They successfully obtained 5 types of 2D metals including bismuth (6.3 angstroms), tin (5.8 angstroms), lead (7.5 angstroms), indium (8.4 angstroms), and gallium (9.2 angstroms)—the thickness of these materials is only 1/200,000 of the diameter of a human hair and 1/1,000,000 of the thickness of an A4 paper. This breakthrough fills a key gap in the 2D material family and overcomes the long-standing problem of difficult separation of non-layered metals. 2D metals are expected to give rise to macroscopic quantum phenomena such as the high-temperature quantum Hall effect, providing core materials for technological innovations such as low-power transistors. Tens of thousands of 2D metal materials are yet to be explored in the future, opening up a new research field.
VII. School of Mechanical Engineering Overcomes Difficulties in Core Components of High-End Mass Spectrometers
Recently, the Precision Manufacturing and Optoelectronic Measurement Technology Team of the School of Mechanical Engineering of a university achieved a key breakthrough in the field of major scientific instruments. The patent related to the core component of the high-end mass spectrometer developed by the team—the ion source lens optical system—was successfully transferred, with a single transfer amount of 10.5 million yuan, setting a new historical high for the university.
This achievement was led by Professor Lei Zili of the team. Through innovative structural design and precision manufacturing processes, it overcame the key technology of stable and controllable thermal ionization plasma beams, breaking the foreign monopoly on core components of high-end mass spectrometers. The technology can be widely applied in many fields such as light industry, energy, and marine equipment. The school has always focused on national major strategic needs and industrial technical bottlenecks, promoted basic research and original innovation through organized scientific research, deepened interdisciplinary integration and achievement transformation, promoted the in-depth integration of the innovation chain and industrial chain, and accelerated the transformation of scientific and technological achievements into real productive forces
VIII. Energy Power Enterprise Industry Technology Innovation Alliance Releases a Series of Major Achievements to Empower the Construction of a New Energy System
On December 22nd, the Achievement Conference of the Energy Power Enterprise Industry Technology Innovation Alliance was held in Hohhot, Inner Mongolia, with the theme of “In-depth Integration of Science and Technology Industry, Strong Engine of New Energy Quality”. It focused on displaying innovative achievements in the energy power field, promoting the integration of industry, university, research and application, and injecting impetus into the construction of a new energy system. The alliance was initiated and established by Inner Mongolia Power Group in Hohhot in June 2025, bringing together more than 70 member units covering power generation, power grid, load, energy storage, data, and innovation chains. It focuses on major common problems in energy transformation, based on the development needs of Inner Mongolia’s new energy system and the construction needs of the new power system, and is committed to key technology research and industrial collaborative development, promoting the high-quality development and industrial upgrading of Inner Mongolia’s energy industry.
Since its establishment, the alliance has achieved remarkable results: carrying out more than 30 collaborative innovation projects, undertaking 2 national key R&D program projects, 2 Inner Mongolia Autonomous Region science and technology “breakthrough” projects, and 2 Inner Mongolia Autonomous Region “list-based” projects, achieving substantial breakthroughs and significant progress in key core technology research; accumulating 268 achievements, displaying 66 physical objects on site, and is expected to drive industrial investment of more than 3 billion yuan; constructing an “electricity – computing power – industry” ecology, promoting the formation of characteristic energy industry chains in multiple regions. Key technological breakthroughs include the development of the world’s first UHV hybrid commutation converter, which solves the world-class problem of new energy transmission in desert and Gobi areas; the grid-forming energy storage equipment was selected into the first batch of (set) major technical equipment by the National Energy Administration, filling the domestic gap in related fields; the first provincial-level “source-grid-load-storage” collaborative dispatching platform in China was built, greatly improving the optimal allocation capacity of energy resources. As of November this year, the installed capacity of new energy in the operation area of Inner Mongolia Power Grid has exceeded 90 million kilowatts, accounting for about 60% of the total installed capacity; the power generation of new energy has exceeded 110 billion kilowatt-hours, accounting for more than 35% of the total power generation of the entire grid, providing strong support for national energy security and high-quality development of the region.
Investment and Financing News
I. Mianbi Intelligence Completes Hundreds of Millions of Yuan in Financing to Boost End-Side AI R&D and Commercialization
On December 23rd, Mianbi Intelligence, a leading enterprise in the end-side intelligence field, recently completed hundreds of millions of yuan in financing. This round was jointly participated by several well-known institutions including Jingguorui, Guoke Investment, and CICC Porsche Fund. The raised funds will be mainly invested in the R&D of high-efficiency end-side large models to accelerate the commercialization of end-side AI. As an early layout enterprise in China’s end-side intelligence field, Mianbi Intelligence has built a complete theoretical system and model product portfolio. Its core MiniCPM end-side model has been large-scale applied in multiple fields such as automobiles and mobile phones, and has established in-depth cooperation with enterprises including Geely, Changan, Volkswagen, and Huawei. The models launched this year, such as Changan Mazda MAZDA EZ-60 and Geely Galaxy M9 equipped with this model, have become benchmark cases in the automotive intelligent cockpit field. Investors generally are optimistic about the prospect of the end-side intelligence track and Mianbi Intelligence’s technological and scenario advantages, believing that it has taken the lead in forming a positive cycle of “theory-technology-scenario-commerce”. The CEO of Mianbi Intelligence stated that the company will take this opportunity to increase investment, continue to lead the end-side AI market, and promote efficient end-side large models to empower massive terminals.
II. Guangzihang Technology Completes Angel Round Financing, Led by K2VC to Support Silicon Photonics Sensing Industrialization
On December 23rd, Guangzihang Intelligent Technology (Changzhou) Co., Ltd. (referred to as “Guangzihang Technology”) announced the completion of the angel round financing, led by K2VC and followed by Qitai Capital. The raised funds will be mainly used for the development of standardized silicon photonics sensors and system products, accelerating the industrial application of related technologies. Founded in September 2023, Guangzihang Technology focuses on the R&D of silicon-based photonic sensing chips, as well as the product development and application innovation of standardized silicon photonics sensors and systems. Its core products include industrial-grade passive intelligent sensors such as silicon photonics acceleration, pressure, temperature, and acoustic sensors, as well as high-speed silicon photonics sensing query instruments, which can adapt to complex and extreme environments that traditional electrical measurement sensors are difficult to handle, such as multi-static electricity, high and low temperatures, and strong electromagnetic fields. Its silicon photonics sensing system can be widely used in key industries such as rail transit, battery cells, nuclear energy, coal mining, aerospace, helping customers achieve precise detection of micro-changes in physical quantities, and 24/7 real-time monitoring and intelligent operation and maintenance. This financing will provide capital support for the company’s technological R&D iteration and industrialization, accelerating the penetration and application of silicon-based photonic sensing technology in the high-end industrial testing field.
III. Huguang Quantum Completes Tens of Millions of Yuan in Series A Financing, Tsinghua-Backed Team Leads Quantum Software Industrialization
On December 22nd, Beijing Zhongke Huguang Quantum Software Technology Co., Ltd. (referred to as “Huguang Quantum”) announced the completion of tens of millions of yuan in Series A financing, exclusively invested by Beijing Information Industry Development Investment Fund. The raised funds will be mainly used to expand the R&D team and accelerate core technology R&D to respond to the new software needs of the industry. Founded in 2020, Huguang Quantum focuses on the R&D and industrialization of quantum software and quantum computing applications, relying on the technical support of the Institute of Software of the Chinese Academy of Sciences. More than 90% of the company’s core team holds master’s or doctoral degrees. The founder Ying Shenggang is a doctoral graduate from Tsinghua University, with profound academic background and scientific research strength. Its independently developed quantum program design and verification platform and other products have served multiple mainstream quantum computers in China. This financing will focus on two major directions: first, adapting to the trend of distributed chips and developing hardware-software co-design protocols and solutions; second, building an efficient quantum computing algorithm library and expanding the talent pool. Investors recognize its leading quantum software technology strength, and the two parties will work together to promote the development of the quantum computing industry and provide software support for the regional quantum computing industry.
IV. Led by Post-95 Doctoral Team, Langyi Robotics Completes Tens of Millions of Yuan in Angel+ Round Financing
On December 22nd, Langyi Robotics announced the completion of tens of millions of yuan in Angel+ round financing. Following the angel round financing completed in July, Langyi Robotics has received continuous favor from the capital market within half a year. The angel round and Angel+ round financing have successively introduced well-known institutions such as InnoAngel Fund, Jiadao Capital, Optics Valley Financial Holding, Jiangyin Talent Fund, and MiraclePlus. The funds from the two rounds will focus on core directions such as the R&D and mass production of embodied navigation modules, the upgrading of spatial intelligence algorithms, the large-scale expansion of multiple scenarios, and the ecological co-construction and upgrading with leading robot manufacturers, striving to promote robots from “functional demonstration” to “fully autonomous and practical”. Langyi Robotics focuses on providing intelligent solutions for the new generation of general-purpose robots, with core technologies covering spatial understanding, autonomous movement, and autonomous operation of general-purpose robots. The company is led by Yang Hongcheng, a post-95 artificial intelligence doctor from Huazhong University of Science and Technology. All core members graduated from well-known universities at home and abroad. The proportion of R&D personnel reaches 75%, with more than ten years of experience in spatial intelligence algorithms and robot product development, and strong technical strength. Relying on the “scenario-data-model” technical closed loop, the company has established cooperation with dozens of leading robot manufacturers, and the market share of related products is leading. This financing will further help it deepen industrial chain collaboration, accelerate large-scale landing in multiple scenarios, build a solid “navigation infrastructure” for the embodied intelligence era, and promote the high-quality development of the general-purpose robot industry.
V. Noitom Robotics Completes Pre-A+ Round Financing, Led by Qiming Venture Partners
On December 22nd, Noitom Robotics announced the completion of the Pre-A+ round financing, led by Qiming Venture Partners, participated by institutions such as 5Y Capital and Legend Capital, with Matrix Partners China and InnoAngel Fund making follow-up investments and oversubscription. After completing the Pre-A round and this round of financing, the company has raised a total of hundreds of millions of yuan, which will be mainly used for the R&D of multi-modal data collection and processing technology, the construction of large-scale data production systems, the improvement of core technical and engineering teams, and the enhancement of product delivery and service capabilities, laying a solid foundation for Noitom Robotics’ long-term development worldwide. Noitom Robotics focuses on providing high-quality and scalable training data and related infrastructure capabilities for the embodied intelligence and humanoid robot industry, with data as the core delivery interface. Founded by Dr. Dai Ruoli, a senior technical expert in the field of motion capture and human-computer interaction, Dr. Dai co-founded Noitom Ltd. before establishing Noitom Robotics, and has been deeply engaged in the field of human motion digitization for more than ten years. As the chief technical and product person in charge, he helped the enterprise gain 70% of the global professional motion capture market share, successfully delivered tens of thousands of motion capture systems, and established a leading position in the industry. Relying on the mature motion capture and human-computer interaction technology system, the company has built a human-centric multi-scenario data collection path, and its related capabilities have been verified in the delivery practice of serving dozens of humanoid robot enterprises and embodied intelligence model customers around the world. Investors recognize its full-stack data capabilities and industrial value. This financing will accelerate the engineering construction of its “data factory”, strengthen the cross-ontology data adaptation capability, and build a solid data foundation for the development of the embodied intelligence industry.
VI. Tsinghua-Backed Qianjue Technology Completes Nearly 100 Million Yuan in Pre-A++ Round Financing to Boost Embodied Brain Technology R&D and Commercialization
On December 22nd, Qianjue Technology, incubated from the Tsinghua University Brain-Inspired Computing Research Center, announced the completion of nearly 100 million yuan in Pre-A++ round financing. This round was jointly participated by six well-known investment institutions and existing shareholders, with Maple Pledge acting as the long-term private equity financing advisor. The raised funds will be mainly used for deepening core technology R&D, expanding the top talent team, and accelerating global commercial layout, promoting the large-scale landing of embodied intelligence in multiple scenarios. Qianjue Technology focuses on the R&D and application of decision-making and planning large models in the field of embodied intelligence, with its niche benchmarking against the US leading enterprise Physical Intelligence. The company adopts an innovative brain-inspired partitioned architecture, realizing full-stack independent control from underlying chips to upper-layer algorithms. It has completed the pre-training of three generations of embodied brains, which can independently realize the full closed loop of “perception-decision-action”, and can autonomously reconstruct and continue execution after task interruption. Its “brain in a vat” architecture can be cross-morphologically adapted to various robots, with core advantages of no need to transform the use environment and efficient response to emergencies, breaking the penetration bottleneck of traditional solutions. This financing will further strengthen its technical barriers, promote the large-scale application of embodied brains in multiple fields, and help the robot industry leap from “functional demonstration” to “fully autonomous and practical”.
VII. Focusing on the Synthetic Biology Manufacturing Track, Weihe Biology Completes Seed Round Financing
On December 22nd, Weihe Biology successfully completed the seed round financing, led by Quanhua Life. The raised funds will be mainly used for the construction of R&D platforms, the building of scientific research teams, and the pilot production of core products, accelerating the biomanufacturing process of high-value-added new food raw materials and providing green and sustainable solutions for the big health industry. Founded in October 2025 and settled in the Beijing Agricultural Zhongguancun Science and Technology Park, Weihe Biology focuses on the construction and optimization of high-efficiency cell factories, and the green biomanufacturing of functional proteins and small-molecule active substances. The company’s founding team is led by doctors with international scientific research background and industrialization experience, and has chassis strain development technology based on industrial breeding and synthetic biology regulation, which can realize the stable production of target products and has complete industrialization capabilities. Investors recognize the team’s technical accumulation and transformation execution capabilities, and the two parties will carry out in-depth cooperation in chassis cell development, process optimization and other aspects. This financing comes at a critical stage when the company is moving from technical verification to large-scale R&D, which will help it redefine the production path of functional raw materials and promote the industrial application of synthetic biology technology in the fields of functional food and nutrition and health care.
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